In an interview with Grazia, the reality TV star said that she was frightened while figuring out how to care for West by herself, with her four young children in the house.
"Kanye had it way at the beginning, when nobody really knew what was going on," Kardashian said.
"It was so scary and unknown. I had my four babies and no one else in the house to help."
The Keeping Up With The Kardashians star said she had to change her husband's sheets while wearing gloves and a face shield, calling it "really a scary time".
"It was a challenge because it was so unknown."
In an interview with Forbes published in July, West revealed he had contracted the deadly virus in February.
The 'Lift Yourself' rapper described having "chills, shaking in the bed, taking hot showers and looking at videos telling me what I'm supposed to do to get over it."
He told the outlet of his experience with the virus: "I remember someone had told me Drake had the coronavirus and my response was Drake can't be sicker than me!"
In that same interview, West said he was "extremely cautious" about the idea of a COVID-19 vaccine, calling them "the mark of the beast".
"They want to put chips inside of us, they want to do all kinds of things, to make it where we can’t cross the gates of heaven," he said.